In the study, six weeks of induction of obesity with a Western diet resulted in significantly higher energy intake and increased body weight versus a lower-fat diet.
Daily FE supplementation attenuated body weight gain, white adipose tissue (WAT) expansion, and stage 1–2 NAFLD in both male and female Western diet-fed rats, and increased mating frequency and number of litters over WD-fed controls, at least in part. By relieving oophoritis and atresia.
The report’s authors, from McMaster University Medical Center State, previously showed that a nearly identical multi-ingredient supplement effectively attenuated body weight gain and WAT expansion in male DIO rats fed a high-fat diet (60% of total calories).
The present study aimed to extend these findings to both male and female mice fed a Western diet (42% of total calories and 345 g/kg sucrose) and demonstrate the effects of lipolysis in the liver with attenuation of cell senescence, inflammation and apoptosis. . (Stage 1 – 2 NAFLD).
“We conclude that multi-ingredient supplementation of specific antioxidants, vitamins, and plant extracts may be effective for improving fertility in overweight and obese couples and should be considered as a viable adjunctive therapy in future clinical trials.. the researchers stated.
“Collectively, our preclinical studies indicate that both central and peripheral factors, including appetite suppression, enhanced lipolysis, induction of WAT browning, and anti-inflammatory effects, lead to marked weight loss benefits.”
modern day epidemic
Recent advances in modern times have created an environment that is highly obese for many, tailor-made for relaxed lifestyles. However, obesity represents a complex, multifactorial epidemic, leading to oxidative damage, inflammation, and mitochondrial dysfunction, and ultimately affecting major body organs. As a result, there is an increased comorbidity and risk of death from non-communicable diseases, such as cardiovascular disease (CVD) and type 2 diabetes (T2DM).
In addition, excessive weight gain has also been linked to an increased risk of infertility, with evidence highlighting cases of hyperandrogenism in men, to ovulatory dysfunction in women, as well as higher risks of birth defects and stillbirths in offspring.
Thus, the complex nature of obesity requires the establishment of effective multifactorial prevention and treatment strategies, including behavioral and lifestyle modifications. As part of this treatment, interest in the potential use of multi-ingredient nutritional supplements has grown, following increasing evidence demonstrating the health benefits of the antioxidants, vitamins, and botanicals studied.
Some evidence has suggested weight loss effects after consuming caffeine and plant polyphenols, mostly attributed to thermogenic and suppressant effects. Additionally, synergistic weight loss has been reported from certain antioxidants, along with anti-inflammatory benefits. However, the evidence is still weak for this region.
Five-month-old male and female mice were given either a low-fat (LF) diet or a high-fat/sucrose (HE) Western diet over the course of six weeks. For another six weeks, the mice were fed an LF, HF or HF diet combined with a ‘fertility enhancer’ supplement.
The supplement is formulated with a blend of Antioxidants (Alpha Lipoic Acid, Coenzyme Q10, Vitamin E), Phytonutrients (Green Tea, Green Coffee, Forskolin), Vitamins (Folic Acid), Amino Acids (L-Arginine), ω3 PUFAs (EPA). and DHA), and creatine monohydrate
It was observed that FE supplementation helped attenuate body weight gain, WAT amplification, liver fat levels, and post-stage 1-2 NAFLD in both male and female mice that ingested FE supplementation.
After the controlled mating and pregnancy period, it was observed that more litters resulted (4 vs 0) and there was greater copulation success (67% vs 0%) in rats fed FE, compared to control diets.
“Collectively, our preclinical studies indicate that both central and peripheral factors, including appetite suppression, enhanced lipolysis, WAT stimulation, and anti-inflammatory effects, lead to marked weight loss benefits,” she says. concluded the researchers.
Polyphenols exhibit antioxidant (AO) properties that may attenuate the production of reactive oxygen species (ROS) induced by high-fat/sucrose diets and energy excess, thereby attenuating insulin resistance, oxidative damage, and inflammation in insulin-sensitive tissues.
“Some evidence also suggests that polyphenols may protect against non-alcoholic fatty liver disease, which is likely related to the antioxidant response. Other AOs, such as coenzyme Q10 (CoQ10), α-lipoic acid (α-LA), and vitamin E (α-tocopherol), may provide synergistic weight loss, antioxidant, and anti-inflammatory benefits.they explain in relation to their observations.
While the findings are in line with previous studies and observed mechanisms of action, the use of a small animal sample highlights the need for future research using human randomized controlled trials to establish a causal relationship.
“A multi-ingredient supplement protects against obesity and infertility in Western diet-fed rats”
Mats I. Nelson, Linda May, Lisa G. Roek, Matthew R. Voda, Ashley Law, Bart B.